I have put coons down with one shot to the back of the head and neck area with 22 short solid nose ammo,their small and don,t go bang,if their in a live trap.its easier to do,if I was using a pellet rifle i would think a 22 short would be just as safe,just remember to be sure of your shot before you pull the trigger,and make sure your rifle sights are set to put every shot in or near the same hole at 20 yards,,it can be done,im sure they are hunters here that agree,,but a shot on any moving target is difficult,,thats where the (guage) makes the difference,,#4 on better does the job,,good luck