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This was our experience with one of the very best dogs I have ever known. Cassidy was a Bouvier/shepard, and my young daughter's best friend. We noticed him favoring his rt. hind leg and took him to the vet, who told us it was probably arthritis, and put him on Rimadyl (a pain med). It seemed to help for a few months (he was 10 1/2 yrs old at the time). When the Rimadyl seemed to stop working, we took him back to the vet, and they X-rayed his femuf/knee joint. It showed a thickening of the knee where it meets the femur, and he was diagnosed with osteo. We were told we could do a biopsy to be sure, and amputate, but that wouldn't buy any more time if it had matastasized to the lungs. I suggested a lung X-ray, which they did, and it showed shadowing in the lungs. It was one of the worst days of my life. We decided to do all we could to keep him comfortable and happy for as long as we could. When he started whining when trying to get up/lie down, and obviously limping more, despite the pain meds and all the "anti cancer" natural/herbal treatments I could get a hold of, we had the vet come out to the property and help us let him go on a beatiful, sunny fall day. It absolutely sucked, and I'm tearing up just writing about it. He lived maybe 2 months after the diagnosis, and was 11 1/2 when he died.
I was listening to a radio show about end of life decisions, regarding pets, with a veterinarian. He basically said that, with something like osteo, amputation and chemo put such a stress on the animal, that the best thing can be to do what we did. It was a little comforting to hear that spending thousands of $$ to possibly get a few more months was more likely to cause more pain, which the dog can't possibly understand (esp. w/the chemo).
I'm so sorry for you and your friend. She's so young - that must be almost the hardest part. You are certainly not alone with this experience, and my heart goes out to you.