Fred's Hens, the moderator had said recently that he gave it continuously in a weak dose for several weeks when they got on dirt after he had an outbreak for the first time. Michael Apple recommends using it 5 days every 3 weeks until 7 months I believe. I don't think amprollium really blocks thiamine, but it mimics thiamine in the coccidia oocyst or organism. Here is what is on the website:
How CORID works
Structurally, CORID mimics thiamin (Vitamin B1) which is required by coccidia for normal growth and reproduction. When coccidia ingest CORID, they experience thiamin deficiency and starve from malnutrition. CORID has been experimentally administered at many times the recommended dosage and duration with no signs of toxicity.
I agree. The protozoa apparently is "starved" of thiamine by the amprollium, as I understand it, by taking in the substitute. This is as much as I know, and it isn't much.

Folks often feed medicated (amprollium laced) feed all 18 weeks of a chick's life. Since we feed unmedicated feed, supplementing with "medicated water" so to speak, is our precaution. To date, it has worked well.
I've recently cut back to the 1/4 teaspoon "recipe" and used it for a shorter window of time with good results.
All that said, I am not prepared to get caught off-guard, as I foolishly was during an unexpected, virulent outbreak a year or so ago. One lives and learns. Hopefully.