So I did some research, and it looks like according to Duck DVM the recommended duration of doxycycline to treat mycoplasma in ducks is 21 days, not 7. That could be why she seemed better but then got sick again after you stopped giving it.

Here's what I would do: stop the doxy, and switch to Denagard, if you can get it in your country. What country are you in? Denagard is very effective against Mycoplasma, so if that's what she has, it should wipe it right out. And you just have to put it in their water. Well, it will wipe out the symptoms - mycoplasma is a chronic disease, so if it is mycoplasma, they will always have it from now on.

Do either of the ducks have any kinds of neurological symptoms, like head or neck tremors or incoordination? I ask because I'm also slightly worried about riemerella anatipestifer being possible. It sometimes causes respiratory symptoms in addition to the neurological ones. Here's some info on this disease:

Riemerella anatipestifer Infection
This bacterial disease of ducks is also known as Pasteurella anatipestifer infection, infectious serositis and New Duck disease. Anatipestifer infection causes high mortality, weight loss and condemnation. In the acute form, listlessness, eye discharge and diarrhea are commonly seen. Ducks show incoordination, shaking of the head and twisted neck. Birds are commonly found on their backs, paddling their legs. Typical lesions found in dead birds are infected air sacs, membranes covering the heart and liver, and meningitis. Preventive management and vaccination are effective means of control. Penicillin, enrofloxacin and sulfadimethoxine-ormetoprim (0.04-0.08% in feed) are effective in reducing mortality.

Also, based on the symptoms it seems like it could possibly be aspergillosis also, but let's try for MG like the vet thought first.

Now, about the bumblefoot, can you post a picture of the bottom of her foot? Just applying things externally may not be enough, a lot of times the infection needs to be removed. If it's not removed, she won't get better, unless it's a mild case that was caught early.
 
@ Pyxis? @Maryam. how is she doing today?
Hi sorry i answered late, i didn't have access to internet.
She didn't throw up again but she's eating less and she's still laying an egg a day and she seems weak :( I took her to the same vet again, he said she has to repeat doxycycline again! But i have a feeling that he's diagnosing wrong
 
So I did some research, and it looks like according to Duck DVM the recommended duration of doxycycline to treat mycoplasma in ducks is 21 days, not 7. That could be why she seemed better but then got sick again after you stopped giving it.

Here's what I would do: stop the doxy, and switch to Denagard, if you can get it in your country. What country are you in? Denagard is very effective against Mycoplasma, so if that's what she has, it should wipe it right out. And you just have to put it in their water. Well, it will wipe out the symptoms - mycoplasma is a chronic disease, so if it is mycoplasma, they will always have it from now on.

Do either of the ducks have any kinds of neurological symptoms, like head or neck tremors or incoordination? I ask because I'm also slightly worried about riemerella anatipestifer being possible. It sometimes causes respiratory symptoms in addition to the neurological ones. Here's some info on this disease:



Also, based on the symptoms it seems like it could possibly be aspergillosis also, but let's try for MG like the vet thought first.

Now, about the bumblefoot, can you post a picture of the bottom of her foot? Just applying things externally may not be enough, a lot of times the infection needs to be removed. If it's not removed, she won't get better, unless it's a mild case that was caught early.
Hi, sorry for the delayed response. Thank you for taking the time to help daisy, i appreciate it
I took her for a vet visit again but the thing is the vet doesn't even check her, he just prescribes things. I mean daisy looked much better before having doxy. So i still don't know her illness. I've been researching, the disease seems to be chronic cause the symptoms showed then she seemed to be cured and a month later the Same symptoms shows again.
I asked the vet about replacing doxy with something else he said doxy's fine(which i don't agree with him of coure)
She got sick and threw up while using doxy(on day 6) and she had doxy for another day.( by vet's order)
Unfortunately her symptoms seems to be many illnesses' symptoms.
None of them have neurological symptoms.
People here mostly keep dogs and cats as pet, therefore most of the vets are not bird specialized and We don't have much access to all birds medicine.
Daisy keeps laying an egg a day although she's weak.
This photo is from two weeks ago, after applying tetracycline her foot seems to be better.
 

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Hi, sorry for the delayed response. Thank you for taking the time to help daisy, i appreciate it
I took her for a vet visit again but the thing is the vet doesn't even check her, he just prescribes things. I mean daisy looked much better before having doxy. So i still don't know her illness. I've been researching, the disease seems to be chronic cause the symptoms showed then she seemed to be cured and a month later the Same symptoms shows again.
I asked the vet about replacing doxy with something else he said doxy's fine(which i don't agree with him of coure)
She got sick and threw up while using doxy(on day 6) and she had doxy for another day.( by vet's order)
Unfortunately her symptoms seems to be many illnesses' symptoms.
None of them have neurological symptoms.
People here mostly keep dogs and cats as pet, therefore most of the vets are not bird specialized and We don't have much access to all birds medicine.
Daisy keeps laying an egg a day although she's weak.
This photo is from two weeks ago, after applying tetracycline her foot seems to be better.

What country are you in? Trying to see if I can find anything you can buy over the counter that would help. These guys say they ship worldwide, can you order this and have it shipped to you? https://globalpigeonsupply.com/products/all-in-one-powder-100-gram

From the sounds of the symptoms, which are the sneezing, coughing, wheezing when breathing, and the fact that your second duck seems to now have caught it, I think it's safe to say that whatever it is is respiratory related and it's contagious. That rules out things that affect an individual duck like cancer, and the fact that she's still laying an egg a day (that I assume is normal since you didn't say otherwise) helps to rule out reproductive issues like internal laying, etc. Plus those generally aren't contagious so it wouldn't make sense that your second duck is now showing symptoms if it was something like that.

Do either of them stretch their necks and open their beaks as if gasping for breath? Have you wormed them recently, and if so what did you use?
 
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What country are you in? Trying to see if I can find anything you can buy over the counter that would help. These guys say they ship worldwide, can you order this and have it shipped to you? https://globalpigeonsupply.com/products/all-in-one-powder-100-gram

From the sounds of the symptoms, which are the sneezing, coughing, wheezing when breathing, and the fact that your second duck seems to now have caught it, I think it's safe to say that whatever it is is respiratory related and it's contagious. That rules out things that affect an individual duck like cancer, and the fact that she's still laying an egg a day (that I assume is normal since you didn't say otherwise) helps to rule out reproductive issues like internal laying, etc. Plus those generally aren't contagious so it wouldn't make sense that your second duck is now showing symptoms if it was something like that.

Do either of them stretch their necks and open their beaks as if gasping for breath? Have you wormed them recently, and if so what did you use?
I'm from Iran, thanks for mentioning this website i'll check it.
My second duck's eyes are not watery anymore but the sneezing persists; she doesn't have any other symptoms (like diarrhea, losing appetite..)for now
Laying an egg a day is normal for both of them, they both lay an egg almost everyday but now that she is sick i'm worried about her getting weaker by laying egg.
I really hope it's just a simple cold or mild infection that is not serious.
In summer due to the temperature they used to gasp to breath but not with stretching neck..
They have apple cider vinegar in their water once in a while for preventing worms, do you think that's enough?
 

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