I have little scars all over my forearms from the scratches I got cutting all the hardware cloth for my first run (8'x3') with a pair of wire cutters, attaching the hardware cloth with a low-power electric stapler. Fortunately a pneumatic stapler was lent to me for the cause once a friend realized I was doing it by hand. I had two other people help me with that run.
I built the second run, which is nearly three times the size (8'x8'), all by myself with a pair of tin snips, hammer, nails, screws and cable ties and the thing is absolutely impenetrable.
Having the right tools for the job makes life a LOT easier.
Edited to add: As mentioned, leather gloves are key when working with hardware cloth. I found the cable ties to be a surprisingly quick and effective means of attachment, and it has been very secure. I used 14" outdoor cable ties for the 2"x4"s, 11" outdoor cable ties for the 2"x3"s and 8" outdoor cable ties for the 2"x2"s.