Denagard Dosage

ChicKat

Crowing
Premium Feather Member
Many websites, including the one mentioned, sell products for poultry that aren't approved for use in poultry, some are even banned (Baytril, Cipro, metronidazole). It's up to us to do our homework and decide if it's worth using such drugs. We should also verify dosing info from places like Twin City as often the directions listed are *not* correct.

-Kathy
Right on target...but the twin cities directions are correct - right? We say 1TBSP/gallon or 1/2TBSP for gallon - and that's the same as 3teasp/gallon or 1 1/2teasp per gallon.

The Twin cities price is really good/fair IMO - and the size would be convenient too for most people and the cash outlay is less......
 
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casportpony

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Quote: Is that correct? Have you seen any info published from the mfg on treating poultry with it? I looked awhile ago and can't remember what I found. Gonna look again!


-Kathy
 

casportpony

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https://web.archive.org/web/2013081...com/products/en/denagard_premix_poultry.shtml

Denagard
Premix (Tiamulin)


Product information on this website is for Non-U.S. residents only and is provided by Novartis Animal Health Inc. for general purposes only. Many veterinary products listed are available upon prescription only, and not all such products may be available in all countries. The product information is not intended to provide complete medical information.SHOULD YOUR ANIMAL HAVE A MEDICAL CONDITION, PROMPTLY SEE YOUR OWN VETERINARIAN. WE DO NOT OFFER PERSONALIZED MEDICAL DIAGNOSIS OR ANIMAL-SPECIFIC TREATMENT ADVICE. You should always obtain complete medical information about your veterinary product prescription (including their beneficial medical uses and possible adverse effects) by discussing the appropriate use of any veterinary product directly with the prescribing veterinarian.
Veterinary professionals may obtain complete medical information from the product's information leaflet. Information on these products may vary by country. Animal owners and veterinarians should check with local medical resources and regulatory authorities for information appropriate to their country. In addition, current regulations in many countries limit (or even prohibit in some instances) the ability of Novartis Animal Health Inc. to provide information and/or to respond directly to questions regarding its prescription products. Novartis Animal Health Inc., however, will respond to inquiries from and provide information to your qualified health care professional in accordance with local regulations.
Premix
45% WSG
12.5% Solution
Product Type
Oral antibiotic intended for preventive and therapeutic in feed medication in pigs and poultry.
Description and Composition
DENAGARD Premixes are manufactured with a gel-coated tiamulin hydrogen fumarate concentrate. Gel-coating of the active substance improves stability, reduces dustiness and ensures consistent mixing and dispersal in finished feed. DENAGARD Premix for medicated feed contains 20 mg (2% Premix) or 100 mg (10% Premix) tiamulin hydrogen fumarate per gram of product.
Properties
Tiamulin is a bacteriostatic agent, belonging to the group of pleuromutilins. It has a wide spectrum of activity but is particularly active against Brachyspira, Lawsonia and Mycoplasma species. Unlike other antibiotics intended for in-feed medication, tiamulin belongs to a category of antibiotics which is not used in human medicine.
Indications
Treatment and control of Mycoplasma infections (enzootic pneumonia, chronic respiratory disease) and porcine respiratory disease complex. It has a synergistic activity with tetracyclines against other primary (A.pleuropneumoniae, B.bronchiseptica) and secondary (P.multocida) respiratory pathogens.

DENAGARD is particularly indicated for the control, prevention and treatment of swine dysentery (B.hyodysenteriae), porcine colonic spirochaetosis (B.pilosicoli)and porcine proliferative enteropathy (L.intracellularis).
Dosage and administration

Pigs:
  • Control of swine dysentery: 1.5 – 2 mg tiamulin hydrogen fumarate/kg bodyweight (equivalent to an inclusion level of 30-40 ppm in the finished feed)
  • Treatment of swine dysentery and ileitis: 6 – 8 mg tiamulin hydrogen fumarate /kg bodyweight (equivalent to an inclusion level of 100-150 ppm in the finished feed)
  • Control of mycoplasmal pneumonia: 2 mg tiamulin hydrogen fumarate/kg bodyweight (equivalent to an inclusion level of 40 ppm in the finished feed)
  • Treatment of PRDC (porcine respiratory disease complex): 6 – 10 mg/kg bodyweight (equivalent to an inclusion level of 100-200 ppm in the finished feed)
Chickens:
  • Prevention and treatment of chronic respiratory disease (CRD) and infectious synovitis in broilers, replacement pullets, laying and breeding hens: 25-50 mg/kg bodyweight per day (25-50 g Denagard 10% Premix / 100 kg bodyweight).
Turkeys:
  • Prevention and treatment of infectious sinusitis and air sacculitis in young poults and breeding turkeys: 25-50 mg/kg bodyweight per day (25-50 g Denagard 10% Premix / 100 kg bodyweight).

Withdrawal Periods
Withdrawal periods according to national registrations.
Special Precautions and Warnings
Do not administer the ionophore anticoccidials salinomycin, monensin or narasin to poultry and pigs receiving therapeutic doses of DENAGARD. Pigs and poultry should not receive products containing ionophores during or for at least seven days before or after treatment with DENAGARD.
Formulations and Packages
DENAGARD 2% and 10% Premix is available in bags of 1kg (10% Premix only), 5 kg and 25kg bags.
 
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casportpony

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https://web.archive.org/web/2013080....com/products/en/denagard_45wsg_poultry.shtml

Denagard
45% WSG (Tiamulin)


Product information on this website is for Non-U.S. residents only and is provided by Novartis Animal Health Inc. for general purposes only. Many veterinary products listed are available upon prescription only, and not all such products may be available in all countries. The product information is not intended to provide complete medical information.SHOULD YOUR ANIMAL HAVE A MEDICAL CONDITION, PROMPTLY SEE YOUR OWN VETERINARIAN. WE DO NOT OFFER PERSONALIZED MEDICAL DIAGNOSIS OR ANIMAL-SPECIFIC TREATMENT ADVICE. You should always obtain complete medical information about your veterinary product prescription (including their beneficial medical uses and possible adverse effects) by discussing the appropriate use of any veterinary product directly with the prescribing veterinarian.
Veterinary professionals may obtain complete medical information from the product's information leaflet. Information on these products may vary by country. Animal owners and veterinarians should check with local medical resources and regulatory authorities for information appropriate to their country. In addition, current regulations in many countries limit (or even prohibit in some instances) the ability of Novartis Animal Health Inc. to provide information and/or to respond directly to questions regarding its prescription products. Novartis Animal Health Inc., however, will respond to inquiries from and provide information to your qualified health care professional in accordance with local regulations.
Premix
45% WSG
12.5% Solution
Product Type
Oral antibiotic intended for preventive and therapeutic use in pigs and poultry.
Description and Composition
DENAGARD 45% WSG is a water soluble granulate formulation containing 45g tiamulin hydrogen fumarate per 100g of products. It is used for medication in drinking water.
Properties
Tiamulin is a bacteriostatic agent, belonging to the group of pleuromutilins and acts at the ribosomal level to inhibit bacterial protein synthesis. It has a wide spectrum of activity but is particularly active against Brachyspira, Lawsonia and Mycoplasma species. Tiamulin belongs to a category of antibiotics which is not used in human medicine.
Indications
Treatment and prevention of Mycoplasma infections (enzootic pneumonia, chronic respiratory disease), pleuropneumonia and porcine respiratory disease complex.
DENAGARD is particularly indicated for the treatment of swine dysentery (B.hyodysenteriae)
Dosage and Administration
Pigs:

  • Treatment of swine dysentery: 8.8 mg tiamulin hydrogen fumarate / kg bodyweight for 3-5 consecutive days
  • Treatment of PRDC (porcine respiratory diseases complex): 15 – 20 mg tiamulin hydrogen fumarate / kg bodyweight for 5 – 10 consecutive days
  • Treatment of pleuropneumonia: 20 mg tiamulin hydrogen fumarate / kg bodyweight for 5 consecutive days
Indications

Tiamulin (concentration in water in %)

Product
(in grams)

Water
(in liters)

Treatment
(in days)
Treatment swine dysentery

0.006

1

7.5

3-5
Treatment PRDC

0.012 / 0.018

1

3.75 / 2.5

5 – 10
Treatment pleuropneumonia

0.018

1

2.5

5
Chickens:
  • Prevention of chronic respiratory disease (CRD) and air sacculitis: 12.5 mg tiamulin hydrogen fumarate / kg bodyweight
  • Treatment of chronic respiratory disease (CRD) and air sacculitis: 25 mg tiamulin hydrogen fumarate / kg bodyweight
Turkeys:
  • Prevention of infectious sinusitis and air sacculitis: 12.5 mg tiamulin hydrogen fumarate / kg bodyweight
  • Treatment of infectious sinusitis and air sacculitis: 25 mg tiamulin hydrogen fumarate / kg bodyweight

Indications

Tiamulin (concentration in water in %)

Product
(in grams)

Water
(in liters)

Treatment
(in days)
Prevention CRD / air sacculitis/ infectious sinusitis

0.0125

1.1

4.0

3 days (1stweek of life); 1-2 days (every 3-4 weeks)
Treatment CRD / air sacculitis/ infectious sinusitis

0.025

1.1

2.0

3 – 5
Withdrawal Periods
Withdrawal periods according to national registrations.
Special Precautions and Warnings
Do not administer ionophore anticoccidials (salinomycin, monensin, narasin) to pigs and poultry receiving therapeutic doses of DENAGARD. Pigs and poultry should not receive products containing ionophores during or for at least seven days before or after treatment with DENAGARD.
Formulations and Packages
DENAGARD 45% Water Soluble Granule
  • Box of 70 x 111,2 g or 55,6 g sachets
  • Box of 10 x 1112 g bags
  • Box of 3 x 5000g bags
 
Last edited:

casportpony

Champion
Project Manager
Premium Feather Member
Jun 24, 2012
100,903
250,745
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https://web.archive.org/web/2013092....com/products/en/denagard_12sol_poultry.shtml

Denagard
12.5% Solution (Tiamulin)


Product information on this website is for Non-U.S. residents only and is provided by Novartis Animal Health Inc. for general purposes only. Many veterinary products listed are available upon prescription only, and not all such products may be available in all countries. The product information is not intended to provide complete medical information.SHOULD YOUR ANIMAL HAVE A MEDICAL CONDITION, PROMPTLY SEE YOUR OWN VETERINARIAN. WE DO NOT OFFER PERSONALIZED MEDICAL DIAGNOSIS OR ANIMAL-SPECIFIC TREATMENT ADVICE. You should always obtain complete medical information about your veterinary product prescription (including their beneficial medical uses and possible adverse effects) by discussing the appropriate use of any veterinary product directly with the prescribing veterinarian.
Veterinary professionals may obtain complete medical information from the product's information leaflet. Information on these products may vary by country. Animal owners and veterinarians should check with local medical resources and regulatory authorities for information appropriate to their country. In addition, current regulations in many countries limit (or even prohibit in some instances) the ability of Novartis Animal Health Inc. to provide information and/or to respond directly to questions regarding its prescription products. Novartis Animal Health Inc., however, will respond to inquiries from and provide information to your qualified health care professional in accordance with local regulations.
Premix
45% WSG
12.5% Solution
Product Type
Oral antibiotic intended for preventive and therapeutic use in pigs and poultry.
Description and Composition
DENAGARD 12.5% Solution is an aqueous solution containing 125 mg tiamulin hydrogen fumarate per ml of product. It is used for medication in drinking water.
Properties
Tiamulin is a bacteriostatic agent, belonging to the group of pleuromutilins and acts at the ribosomal level to inhibit bacterial protein synthesis. It has a wide spectrum of activity but is particularly active against Brachyspira, Lawsonia and Mycoplasma species. Tiamulin belongs to a category of antibiotics which is not used in human medicine.
Indications
Treatment and prevention of Mycoplasma infections (enzootic pneumonia, chronic respiratory disease), pleuropneumonia and porcine respiratory disease complex.
Denagard is particularly indicated for the treatment of swine dysentery (B.hyodysenteriae)
Dosage and Administration
Pigs:

  • Treatment of swine dysentery: 8.8 mg tiamulin hydrogen fumarate / kg bodyweight (equivalent to 10 ml DENAGARD 12.5% Solution per 142 kg bodyweight; inclusion level 0.006% tiamulin) for 3-5 consecutive days
  • Treatment of PRDC (porcine respiratory disease complex): 15 – 20 mg tiamulin hydrogen fumarate / kg bodyweight (inclusion level 0.012% - 0.018% tiamulin) for 5 – 10 consecutive days
  • Treatment of pleuropneumonia: 20 mg tiamulin hydrogen fumarate / kg bodyweight (inclusion level 0.018% tiamulin) for 5 consecutive days
Indications

Tiamulin (concentration in water in %)

Product
(in ml)

Water
(in liters)

Treatment
(in days)
Treatment swine dysentery

0.006

1

2.1

5
Treatment PRDC

0.012 / 0.018

1

1.0 / 0.7

5 - 10
Treatment pleuropneumonia

0.018

1

0.7

5
Chickens:
  • Prevention of chronic respiratory disease (CRD) and air sacculitis: 12.5 mg tiamulin hydrogen fumarate / kg bodyweight
  • Treatment of chronic respiratory disease (CRD) and air sacculitis: 25 mg tiamulin hydrogen fumarate / kg bodyweight
Turkeys:
  • Prevention of infectious sinusitis and air sacculitis: 12.5 mg tiamulin hydrogen fumarate / kg bodyweight
  • Treatment of infectious sinusitis and air sacculitis: 25 mg tiamulin hydrogen fumarate / kg bodyweight

Indications

Tiamulin (concentration in water in %)

Product
(in ml)

Water
(in liters)

Treatment
(in days)
Prevention CRD / air sacculitis / infectious sinusitis

0.0125

1

1

3 days (1stweek of life); 1-2 days every 3-4 weeks
Treatment CRD / air sacculitis / infectious sinusitis

0.025

2

1

3 – 5
Withdrawal Periods
Withdrawal periods according to national registrations.
Special Precautions and Warnings
Do not administer ionophore anticoccidials (salinomycin, monensin, narasin) to pigs and poultry receiving therapeutic doses of DENAGARD. Pigs and poultry should not receive products containing ionophores during or for at least seven days before or after treatment with DENAGARD.
Formulations and Packages
DENAGARD 12.5% Solution
  • 1 litre dispensing packs
 
Last edited:

casportpony

Champion
Project Manager
Premium Feather Member
Jun 24, 2012
100,903
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If I have read the above correctly, I think the treatment when using the 12.5% solution is 2ml per liter and preventative is 1ml per liter, which is a little less than 8ml per gallon and 4ml per gallon.


-Kathy
 
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ChicKat

Crowing
Premium Feather Member
If I have read the above correctly, I think the treatment when using the 12.5% solution is 2ml per liter and preventative is 1ml per liter, which is a little less than 8ml per gallon and 4ml per gallon.


-Kathy
Here is the link to the sales info in UK -
http://www.thepoultrysite.com/focus/contents/novartis/novartis_poultry1.pdf

it says:
The dosage for chickens and turkeys is 25 mg tiamulin/kg bodyweight or 100mls of Denagard 12.5% Oral Solution for 500 kgs of bird. Denagard should be administered continuously in the drinking water at a level of 0.025% (250ppm) for 3-5 days to chickens and 5 days to turkey

ETA - I did speak with a very qualified vet about using the product. One reason it isn't 'approved' in the USA is that to FDA trials/tests cost hundreds-of-thousands-of-dollars. Also want to add - I appreciate the info that you provide -- I see your postings a lot on BYC.
 
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