Denagard Dosage

ChicKat

Crowing
Premium Feather Member
Which does work out to about 8ml per gallon, not 16ml per gallon like the Twin City site says.

-Kathy
I think that 8ml is the preventive dose and 16 is the curative dose...

From Google:
Relationship to teaspoon and fluid ounce[edit] In most regions (including the United States, Canada, Japan, New Zealand, South Africa, United Kingdom and the Republic of Korea), one tablespoonful equals three teaspoons. In these regions, one tablespoon is approximately 15 mL, which is about 12 US fl oz

Meanwhile, I'm still working out my strategy to keep my flock MG free. The TVMDL told me that showing is a risk (everything is a risk in our unsanitary world with all the pathogens, right?) -- and that I could predose the chickens that I took to a show, and dose when I got home and I should quarantine the chickens for 30-days.

People who regularly show would scoff. I'm thinking maybe I just take the same 3-chickens to shows, pre-dose like the vet said - and finish up the dose upon return home. Keep those three in a tractor as far as possible from the rest of my flock and never ever let them mingle.
 
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casportpony

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Which does work out to about 8ml per gallon, not 16ml per gallon like the Twin City site says.

-Kathy
I think that 8ml is the preventive dose and 16 is the curative dose...

From Google:
[COLOR=008080]Relationship to teaspoon and fluid ounce[edit] In most regions (including the United States, Canada, Japan, New Zealand, South Africa, United Kingdom and the Republic of Korea), one tablespoonful equals three teaspoons. In these regions, one tablespoon is approximately [COLOR=222222]15 mL[/COLOR], which is about [COLOR=222222][SUP]1[/SUP][/COLOR]⁄[COLOR=222222][SUB]2[/SUB][/COLOR] US fl oz[/COLOR]

[COLOR=0000FF]Meanwhile, I'm still working out my strategy to keep my flock MG free.  The TVMDL told me that showing is a risk (everything is a risk in our unsanitary world with all the pathogens, right?) -- and that I could predose the chickens that I took to a show, and dose when I got home and I should quarantine the chickens for 30-days.  [/COLOR]

[COLOR=0000FF]People who regularly show would scoff.  I'm thinking maybe I just take the same 3-chickens to shows, pre-dose like the vet said - and finish up the dose upon return home.  Keep those three in a tractor as far as possible from the rest of my flock and never ever let them mingle.  [/COLOR]

Is my math wrong? Or am I being dense (which happens all too often)? The Denagard literature say treatment is 2ml per liter, right? Or did I read that incorrectly? If treatment is 2ml per liter, and there are almost 4 liters to a gallon, the treatment dose would be a little less than 8ml, not 16 ml.

-Kathy
 

casportpony

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If one believes the below to be true, the *treatment* dose per gallon is 7.57082 ml, which is about 1.5 teaspoons.
This is what I found here: http://www.noahcompendium.co.uk/Nov...w_v_Concentrate_for_Oral_Solution/-28468.html
Denagard 12.5% w/v Concentrate for Oral Solution
Dosage and administration
Pigs: The dosage is 8.8 mg of the active substance per kg bodyweight daily, (equivalent to 10 ml Denagard 12.5% Concentrate for Oral Solution per 142 kg bodyweight) administered in the drinking water of pigs for 3 to 5 days, depending on the severity of the infection and/or the duration of the disease.
The contents of each 1 litre bottle will treat 188 pigs of 25 kg bodyweight for three days or 114 pigs of 25 kg bodyweight for 5 days.
To ensure an intake of 8.8 mg/kg daily, Denagard 12.5% Concentrate for Oral Solution may be administered in one of two ways.
1.​
Administer in approximately one half of the daily water requirements, to ensure consumption of the correct dose. Unmedicated water should be provided each day after the medicated water has been consumed. The dosage rate, calculated on a liveweight basis, is equivalent to 10 ml solution per 142 kg bodyweight
2.​
Administer continuously at a level of 60 ppm of active substance in the drinking water, as the only source of drinking water. The daily requirement should be added to the drinking water at the rate of 9.6 ml solution per 20 litres (4.5 gallons) of water.
Where a water medicator is used the appropriate stock solution should be made up according to the maker's instructions. If there is no response to treatment within 5 days, the diagnosis should be re-established.
Chickens: The dosage for chickens is 25 mg of active substance per kg bodyweight (equivalent to 100 ml of product per 500 kg bodyweight). Tiamulin should be administered continuously at a level of 0.025% (250 ppm) in drinking water (2 ml product per litre of water) for 3 – 5 days and will provide approximately the following daily dosage of tiamulin depending on the age of the bird:
Day old chick: 125 – 150 mg/kg bodyweight
4 week old broiler: 30 – 50 mg/kg bodyweight
10 week old pullet: 30 – 45 mg/kg bodyweight
Layer: 25 mg/kg bodyweight
Turkeys: The dosage for turkeys is 25 mg of active substance per kg bodyweight (equivalent to 100 ml of product per 500 kg bodyweight). Tiamulin should be administered continuously at a level of 0.025% (250 ppm) tiamulin in the drinking water (2 ml product per litre of water) for 5 days and will provide approximately the following daily dosage of tiamulin depending on the age of the bird:
1 week old poult: 70 mg/kg bodyweight
4 week old poult: 50 mg/kg bodyweight
8 week old poult: 20 – 30 mg/kg bodyweight
20 week old poult: 25 mg/kg bodyweight
Monitor water intake at frequent intervals during medication.
Fresh solutions of tiamulin-medicated drinking water should be made up each day.



-Kathy
 
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casportpony

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Also found this: http://www.noahcompendium.co.uk/Nov...w_v_Concentrate_for_Oral_Solution/-28469.html

Denagard 12.5% w/v Concentrate for Oral Solution
Contra-indications, warnings, etc
Withdrawal Periods
Pigs: 2 days
Chickens: 2 days
Eggs: Zero
Turkeys: 5 days
Contra-indications
Do not use in animals hypersensitive to the active ingredient or any of the excipients.
Animals and birds should not receive products containing monensin, narasin or salinomycin during or for at least seven days before or after treatment. Severe growth depression or death may result.
Concomitant use of tiamulin and the ionophore anticoccidial maduramicin may lead to a mild to moderate growth depression in chickens. The situation is transient and recovery normally occurs within 3 – 5 days following withdrawal of tiamulin treatment. This does not seem to occur with the ionophores lasalocid or semduramicin.
In order to avoid interactions between tiamulin and the incompatible ionophores monensin, narasin and salinomycin, the feed mill supplying the feed should be notified that tiamulin will be used and that these products should not be included in the feed or contaminate the feed.
The feed should be tested for the ionophores prior to use if there is any suspicion that contamination of the feed might occur. If an interaction does occur, stop tiamulin water medication immediately and replace with fresh water. Remove contaminated feed as soon as possible and replace with feed not containing the tiamulin-incompatible ionophores.
Operator warnings
When mixing, direct contact with the skin and eyes should be avoided by wearing impermeable rubber gloves and safety glasses. In case of accidental eye contact, irrigate the eyes thoroughly with clean running water immediately. Seek medical advice if irritation persists. Contaminated clothing should be removed and any splashes on the skin should be washed off immediately. Wash hands after use.
Pregnancy and lactation
Denagard can be used in pregnant and lactating pigs.
Tiamulin may be used in laying and breeding birds as it has been shown to have no adverse effects on egg production, fertility and hatchability in chickens and turkeys.
Precautions
For use in the drinking water of pigs, chickens and turkeys only.
If there is no response to treatment within five days, the diagnosis should be re-established.
Severely affected pigs that do not drink may be treated with Denagard 200 Solution for Injection.
On rare occasions erythema or mild oedema of the skin may occur in pigs following the use of tiamulin hydrogen fumarate.
Water intake may be depressed during the administration of tiamulin to birds. It appears to be concentration dependent with 0.025% (250 ppm) tiamulin reducing intake by approximately 15%. It does not appear to have any adverse effect on overall performance of the birds or efficacy of the product.
There is a relatively high therapeutic index with tiamulin and the likelihood of an overdosage is considered remote, especially as water intake and hence tiamulin intake is reduced if abnormally high concentrations are given. The LD5 for chickens is 1290 mg/kg bodyweight and for turkeys 840 mg/kg bodyweight.
The clinical signs of toxicity in chickens are: vocalization, clonic cramps and lying in a lateral position. Symptoms in turkeys are: clonic cramps, lateral or dorsal position, salivation and ptosis.
If signs of intoxication do occur, promptly remove the medicated water and replace with fresh water.
For animal treatment only.
Keep out of the reach and sight of children.
 

ChicKat

Crowing
Premium Feather Member
No you aren't dense I am --


well a bit conflused anyway.

I'm happy to say that I'm done with treatment - and everyone survived the 1TBSP per gallon.

All of it seems so inexact in a way. Treat 3-5 days --- and after I started the first dose for them at !TBSP I wondered if I should have done 1/2. Then at 3-days should I quit? etc. or should 1 do 5 - what is 3-5 days? split down the middle? do it 4? or just do 3? If there was something to see (I did have a Blue Isbar that had sniffles) - I would do that pen for 5 days. Someone told me that if it says 5- then do 7. The vet at TVMDL said that the continued monthly dose is probably not needed. So I will just keep it to treat birds with the preventive dose before and after a show. Or if something were to flare up. I do remember someone saying someplace that this one isn't dangerous if overdosed or prone to having the organisms develop a resistance if underdosed...so maybe it is okay in the hands of rank amateurs like me.

Frankly Kathy - mm etc. is a foreign language to me. I'm not the best measurer -- is THAT why my cake flopped? They say baking takes precision measurements.
 

dawg53

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I'd be concerned about diseases that denagard doesnt treat and your vet and yourself realize that fact. It's risky taking birds to shows. IB, coryza, ILT are just a few of the common diseases that come to mind and denagard doesnt treat those diseases. These diseases including MG can be transmitted on your clothing, shoes, hands...including from handling infected cages etc... just for your info.
 
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casportpony

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No you aren't dense I am -- 
:oops:

well a bit conflused anyway.

 I'm happy to say that I'm done with treatment - and everyone survived the 1TBSP per gallon.  

All of it seems so inexact in a way.  Treat 3-5 days --- and after I started the first dose for them at !TBSP I wondered if I should have done 1/2.  Then at 3-days should I quit?  etc. or should 1 do 5 - what is 3-5 days?  split down the middle? do it 4?  or just do 3?  If there was something to see (I did have a Blue Isbar that had sniffles) - I would do that pen for 5 days.  Someone told me that if it says 5- then do 7.  The vet at TVMDL said that the continued monthly dose is probably not needed.   So I will just keep it to treat birds with the preventive dose before and after a show.  Or if something were to flare up.  I do remember someone saying someplace that this one isn't dangerous if overdosed or prone to having the organisms develop a resistance if underdosed...so maybe it is okay in the hands of rank amateurs like me.

Frankly Kathy - mm etc. is a foreign language to me.  I'm not the best measurer -- is THAT why my cake flopped?  They say baking takes precision measurements.  

I have heard that one will get better results baking if they *weigh* the ingredients on a scale. One tablespoon of one type of flour will weigh a slightly different amount than another. :D

-Kathy
 

peahenry

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You state that Denagard is not approved in the US. Is that true that it is not approved??
 

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